All cannabinoids, including cannabidiol, attach themselves to the endocannabinoid system in the brain. THC, for example, mostly binds to CB1 and CB2 receptors. CB1 and CB2 receptors play a role in many of the bodily functions that medical marijuana is known to help. CB1 receptors, when stimulated by psychoactive marijuana products, pour out neurotransmitters, which are what cause the ‘high’ feelings.
CBD also affects the CB1 and CB2 receptors, but not directly. When it gets into the brain, it instead stimulates a bouquet of tertiary receptors in the endocannabinoid system.
These include the adenosine receptor, which can help with bone and heart health; serotonin receptors which can help regulate mood and fight depression; and the capsaicin receptor, which is the same receptor spicy food stimulates. It helps regulate body temperature, inflammation, and pain management.
As the body breaks down CBD, the compound acts as a fatty acid amide hydrolase (FAAH) inhibitor. When the FAAH enzyme is blocked, it can disrupt the CB1 receptors throughout the body. FAAH inhibitors have a ton of potential health benefits, however, it’s still controversial. One thing FAAH inhibitors do for certain is disrupt CB1 receptors.
So, not only is CBD non-psychoactive, it actively suppresses the high people get from THC.