The fast onset of #antidepressant action of #CBD and the simultaneous anxiolytic (anti-anxiety) effect would solve some of the main limitations of current antidepressant therapies.”

The hippocampus is a major brain area, and plays a critical role in a variety of brain functions.

An animal study using mice found repeated administration of CBD may help the hippocampus regenerate neurons, which could be useful for treating anxiety or depression. Research shows both SSRIs and CBD may promote neurogenesis. This is significant because evidence suggests that severely impaired neuronal plasticity may influence suicidal behavior. Future research comparing CBD and SSRIs effect on neurogenesis could open up promising new avenues in how we understand depression and how to most effectively treat it.

In recent years, CBD has generated a tremendous amount of interest among consumers, clinicians, and scientists. Why? Not only does evidence suggest CBD counteracts many of THC’s adverse effects, but numerous animal studies and accumulating evidence from human experimental, clinical, and epidemiological studies suggest CBD has powerful anti-anxiety properties. Administered acutely (“as needed”), it appears safe, well-tolerated and may be beneficial to treat a number of anxiety-related disorders, including:

  • . Panic disorder

  • . Obsessive Compulsive Disorder (OCD)

  • . Social phobia

  • . Post-Traumatic Stress Disorder (PTSD)

  • . Generalized Anxiety Disorder (GAD)

  • . Mild to moderate depression

Evidence from animal studies have begun to characterize the details of how CBD acts in the brain, and human studies of patients with and without anxiety disorders are starting to validate CBD’s efficacy as an anti-anxiety treatment. Given the huge social and financial costs of anxiety disorders in the U.S., CBD has the potential to play a significant role in treating a myriad of anxiety-related disorders.

While more research, including large randomized-control trials (RCTs), is clearly warranted to examine the long-term effects and potential for CBD, its demonstrated efficacy and highly favorable safety profile (particularly when compared to currently available drugs) make it a viable alternative or adjunct to currently available pharmaceuticals.

Originally published: Leafy

BLOG How Cannabidiol (CBD) Works for Treating Anxiety.png